Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1280036..1280814 Replicon chromosome
Accession NZ_CP101170
Organism Xanthomonas campestris pv. campestris strain CN05

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag XCCCN05v2_RS05350 Protein ID WP_011038220.1
Coordinates 1280036..1280527 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag XCCCN05v2_RS05355 Protein ID WP_011038219.1
Coordinates 1280524..1280814 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XCCCN05v2_RS05335 1276364..1277239 + 876 WP_011038222.1 30S ribosomal protein S6--L-glutamate ligase -
XCCCN05v2_RS05340 1277889..1278566 + 678 WP_003490678.1 response regulator transcription factor -
XCCCN05v2_RS05345 1278559..1279893 + 1335 WP_019237347.1 HAMP domain-containing sensor histidine kinase -
XCCCN05v2_RS05350 1280036..1280527 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
XCCCN05v2_RS05355 1280524..1280814 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
XCCCN05v2_RS05360 1280889..1281290 - 402 WP_019237348.1 SymE family type I addiction module toxin -
XCCCN05v2_RS05365 1281822..1282445 - 624 WP_228422810.1 dephospho-CoA kinase -
XCCCN05v2_RS05370 1282459..1283322 - 864 WP_223646361.1 A24 family peptidase -
XCCCN05v2_RS05375 1283329..1284588 - 1260 WP_223646360.1 type II secretion system F family protein -
XCCCN05v2_RS05380 1284942..1285382 + 441 WP_223646359.1 pilin -
XCCCN05v2_RS05385 1285502..1285633 + 132 Protein_1045 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1246495..1283616 37121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T251458 WP_011038220.1 NZ_CP101170:c1280527-1280036 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT251458 WP_011038219.1 NZ_CP101170:c1280814-1280524 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References