Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2350371..2351346 Replicon chromosome
Accession NZ_CP101135
Organism Bacillus paranthracis strain Bt C4

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag NLJ82_RS11975 Protein ID WP_002027714.1
Coordinates 2350371..2351108 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag NLJ82_RS11980 Protein ID WP_000588712.1
Coordinates 2351221..2351346 (+) Length 42 a.a.

Genomic Context

NLJ82_RS11945NLJ82_RS11950NLJ82_RS11955NLJ82_RS11965NLJ82_RS11970NLJ82_RS11975NLJ82_RS11980NLJ82_RS11985NLJ82_RS11990NLJ82_RS12000NLJ82_RS12005NLJ82_RS12010NLJ82_RS11960NLJ82_RS11995
Location: 2345446..2346156 (711 bp)
Type: Others
Protein ID: WP_000787475.1
Location: 2346276..2346683 (408 bp)
Type: Others
Protein ID: WP_000072484.1
Location: 2346789..2346881 (93 bp)
Type: Others
Protein ID: Protein_2275
Location: 2348795..2349277 (483 bp)
Type: Others
Protein ID: WP_000191904.1
Location: 2349445..2350182 (738 bp)
Type: Others
Protein ID: WP_000594123.1
Location: 2350371..2351108 (738 bp)
Type: Toxin
Protein ID: WP_002027714.1
Location: 2351221..2351346 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2351422..2351598 (177 bp)
Type: Others
Protein ID: WP_000852623.1
Location: 2351742..2353211 (1470 bp)
Type: Others
Protein ID: WP_000287524.1
Location: 2353802..2354395 (594 bp)
Type: Others
Protein ID: WP_000265892.1
Location: 2354617..2355150 (534 bp)
Type: Others
Protein ID: WP_000438320.1
Location: 2355140..2355967 (828 bp)
Type: Others
Protein ID: WP_001060777.1
Location: 2347003..2348688 (1686 bp)
Type: Others
Protein ID: WP_002027713.1
Location: 2353288..2353659 (372 bp)
Type: Others
Protein ID: WP_000670601.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NLJ82_RS11945 (NLJ82_11945)2345446..2346156+711WP_000787475.1class I SAM-dependent methyltransferase-
NLJ82_RS11950 (NLJ82_11950)2346276..2346683+408WP_000072484.1VOC family protein-
NLJ82_RS11955 (NLJ82_11955)2346789..2346881+93Protein_2275methyltransferase-
NLJ82_RS11960 (NLJ82_11960)2347003..2348688-1686WP_002027713.1alpha-keto acid decarboxylase family protein-
NLJ82_RS11965 (NLJ82_11965)2348795..2349277+483WP_000191904.1MarR family transcriptional regulator-
NLJ82_RS11970 (NLJ82_11970)2349445..2350182+738WP_000594123.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
NLJ82_RS11975 (NLJ82_11975)2350371..2351108+738WP_002027714.1type II toxin-antitoxin system SpoIISA family toxinToxin
NLJ82_RS11980 (NLJ82_11980)2351221..2351346+126WP_000588712.1hypothetical proteinAntitoxin
NLJ82_RS11985 (NLJ82_11985)2351422..2351598+177WP_000852623.1stage II sporulation protein SB-
NLJ82_RS11990 (NLJ82_11990)2351742..2353211+1470WP_000287524.1beta-Ala-His dipeptidase-
NLJ82_RS11995 (NLJ82_11995)2353288..2353659-372WP_000670601.1DUF5065 family protein-
NLJ82_RS12000 (NLJ82_12000)2353802..2354395+594WP_000265892.1SGNH/GDSL hydrolase family protein-
NLJ82_RS12005 (NLJ82_12005)2354617..2355150+534WP_000438320.1sigma-70 family RNA polymerase sigma factor-
NLJ82_RS12010 (NLJ82_12010)2355140..2355967+828WP_001060777.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T251452 WP_002027714.1 NZ_CP101135:2350371-2351108 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT251452 WP_000588712.1 NZ_CP101135:2351221-2351346 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5M9H7T3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References