251452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2350371..2351346 Replicon chromosome
Accession NZ_CP101135
Organism Bacillus paranthracis strain Bt C4

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag NLJ82_RS11975 Protein ID WP_002027714.1
Coordinates 2350371..2351108 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag NLJ82_RS11980 Protein ID WP_000588712.1
Coordinates 2351221..2351346 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLJ82_RS11945 (NLJ82_11945) 2345446..2346156 + 711 WP_000787475.1 class I SAM-dependent methyltransferase -
NLJ82_RS11950 (NLJ82_11950) 2346276..2346683 + 408 WP_000072484.1 VOC family protein -
NLJ82_RS11955 (NLJ82_11955) 2346789..2346881 + 93 Protein_2275 methyltransferase -
NLJ82_RS11960 (NLJ82_11960) 2347003..2348688 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
NLJ82_RS11965 (NLJ82_11965) 2348795..2349277 + 483 WP_000191904.1 MarR family transcriptional regulator -
NLJ82_RS11970 (NLJ82_11970) 2349445..2350182 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
NLJ82_RS11975 (NLJ82_11975) 2350371..2351108 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NLJ82_RS11980 (NLJ82_11980) 2351221..2351346 + 126 WP_000588712.1 hypothetical protein Antitoxin
NLJ82_RS11985 (NLJ82_11985) 2351422..2351598 + 177 WP_000852623.1 stage II sporulation protein SB -
NLJ82_RS11990 (NLJ82_11990) 2351742..2353211 + 1470 WP_000287524.1 beta-Ala-His dipeptidase -
NLJ82_RS11995 (NLJ82_11995) 2353288..2353659 - 372 WP_000670601.1 DUF5065 family protein -
NLJ82_RS12000 (NLJ82_12000) 2353802..2354395 + 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
NLJ82_RS12005 (NLJ82_12005) 2354617..2355150 + 534 WP_000438320.1 sigma-70 family RNA polymerase sigma factor -
NLJ82_RS12010 (NLJ82_12010) 2355140..2355967 + 828 WP_001060777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T251452 WP_002027714.1 NZ_CP101135:2350371-2351108 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT251452 WP_000588712.1 NZ_CP101135:2351221-2351346 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References