Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6333057..6334657 Replicon chromosome
Accession NZ_CP101125
Organism Pseudomonas nunensis strain In5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NK667_RS27830 Protein ID WP_054617082.1
Coordinates 6333057..6334382 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NK667_RS27835 Protein ID WP_054048289.1
Coordinates 6334379..6334657 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NK667_RS27825 (NK667_27825) 6329867..6332824 - 2958 WP_054617083.1 autotransporter domain-containing protein -
NK667_RS27830 (NK667_27830) 6333057..6334382 + 1326 WP_054617082.1 HipA domain-containing protein Toxin
NK667_RS27835 (NK667_27835) 6334379..6334657 + 279 WP_054048289.1 helix-turn-helix transcriptional regulator Antitoxin
NK667_RS27840 (NK667_27840) 6334744..6335580 - 837 WP_054048291.1 amino acid ABC transporter permease -
NK667_RS27845 (NK667_27845) 6335577..6336398 - 822 WP_054048293.1 ABC transporter substrate-binding protein -
NK667_RS27850 (NK667_27850) 6336511..6337410 + 900 WP_054617081.1 homocysteine S-methyltransferase family protein -
NK667_RS27855 (NK667_27855) 6337531..6338202 - 672 WP_054617080.1 GNAT family protein -
NK667_RS27860 (NK667_27860) 6338221..6338667 - 447 WP_054617079.1 GNAT family N-acetyltransferase -
NK667_RS27865 (NK667_27865) 6338677..6339300 - 624 WP_054617078.1 FMN-binding negative transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 48946.71 Da        Isoelectric Point: 4.9693

>T251446 WP_054617082.1 NZ_CP101125:6333057-6334382 [Pseudomonas nunensis]
MYTLTLQVYTSGNWLDAMTLVFTEPEKGFEGPCRFGYKKDYVATNLEYIDSQFSKAVSARLPLDWDNTSLKKAPAFLLDI
APAGAAKRFLMARVGQDKPEGISADLFLLGRSTPAPIGHMRIKESAEAADDRPAVGFRREEVVARDNTFLEYAYEQGAAI
GGATGAGGEAPKLLMSQGRDGLLYPDAVLSDDQVVQHWFVKFARNRAAQTDQIILKSEFHYYKALHVLGIETIAEDGLAL
EEATKPSLWMKRFDREVTDQGVERLAVESIYSLAGVTVPGSYMNHLEVIQLLARLWKQAGQVDQVPALVSDYLRRDLLNK
ILGNSDNHGRNTSIIRGTDSFRLAPIYDLAPMVMDDEGVTRTTKWPKDLEVAGEVKWREVCDALADIEDPEALFEGLRTD
ANRLLALPDILTASGLPEATMNHPGVALRNLEQRLKTWGLK

Download         Length: 1326 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10276.03 Da        Isoelectric Point: 10.5916

>AT251446 WP_054048289.1 NZ_CP101125:6334379-6334657 [Pseudomonas nunensis]
MTISIDARALLIESIQEGLAQGTLEIGEAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNSVFKPFGL
KMGVVRIRRDFS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References