Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5911197..5911840 Replicon chromosome
Accession NZ_CP101125
Organism Pseudomonas nunensis strain In5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NK667_RS25995 Protein ID WP_054616542.1
Coordinates 5911658..5911840 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NK667_RS25990 Protein ID WP_054047901.1
Coordinates 5911197..5911598 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NK667_RS25970 (NK667_25970) 5906265..5907584 - 1320 WP_054616540.1 LLM class flavin-dependent oxidoreductase -
NK667_RS25975 (NK667_25975) 5907587..5909833 - 2247 WP_054616541.1 TonB-dependent receptor -
NK667_RS25980 (NK667_25980) 5910040..5911080 + 1041 WP_054047806.1 LacI family DNA-binding transcriptional regulator -
NK667_RS25985 (NK667_25985) 5911094..5911225 - 132 Protein_5128 DUF4381 domain-containing protein -
NK667_RS25990 (NK667_25990) 5911197..5911598 - 402 WP_054047901.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NK667_RS25995 (NK667_25995) 5911658..5911840 - 183 WP_054616542.1 type II toxin-antitoxin system HicA family toxin Toxin
NK667_RS26000 (NK667_26000) 5911947..5912861 - 915 WP_054616543.1 LysR family transcriptional regulator -
NK667_RS26005 (NK667_26005) 5912991..5913731 + 741 WP_054616544.1 SDR family oxidoreductase -
NK667_RS26010 (NK667_26010) 5913756..5914643 + 888 WP_054616545.1 SDR family oxidoreductase -
NK667_RS26015 (NK667_26015) 5914767..5915024 + 258 WP_054616546.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6834.95 Da        Isoelectric Point: 10.7495

>T251444 WP_054616542.1 NZ_CP101125:c5911840-5911658 [Pseudomonas nunensis]
MRSREMIRMIEGDGWYLVAVKGSHHQYKHSHKPGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14582.36 Da        Isoelectric Point: 4.4829

>AT251444 WP_054047901.1 NZ_CP101125:c5911598-5911197 [Pseudomonas nunensis]
MKFPVVLHKDADSEYGVIVPDVPGCFSAGSTVAQAFENVKEALSLHYEGLVADGDPLPQVREIDAHLDNPDYAGGVWGVV
EFDITPYFGKAVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References