Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 4362532..4363571 | Replicon | chromosome |
| Accession | NZ_CP101125 | ||
| Organism | Pseudomonas nunensis strain In5 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | NK667_RS19030 | Protein ID | WP_054615741.1 |
| Coordinates | 4362996..4363571 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A9E8B8C7 |
| Locus tag | NK667_RS19025 | Protein ID | WP_054049618.1 |
| Coordinates | 4362532..4362999 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NK667_RS19000 (NK667_19000) | 4357686..4358315 | - | 630 | WP_177331445.1 | DUF5666 domain-containing protein | - |
| NK667_RS19005 (NK667_19005) | 4358551..4359756 | + | 1206 | WP_054615738.1 | MFS transporter | - |
| NK667_RS19010 (NK667_19010) | 4359977..4360633 | + | 657 | WP_054615739.1 | peroxiredoxin-like family protein | - |
| NK667_RS19015 (NK667_19015) | 4360682..4361401 | + | 720 | WP_054049404.1 | SDR family oxidoreductase | - |
| NK667_RS19020 (NK667_19020) | 4361560..4362447 | + | 888 | WP_054615740.1 | LysR family transcriptional regulator | - |
| NK667_RS19025 (NK667_19025) | 4362532..4362999 | + | 468 | WP_054049618.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NK667_RS19030 (NK667_19030) | 4362996..4363571 | + | 576 | WP_054615741.1 | PIN domain-containing protein | Toxin |
| NK667_RS19035 (NK667_19035) | 4363729..4364133 | - | 405 | WP_054049397.1 | hypothetical protein | - |
| NK667_RS19040 (NK667_19040) | 4364148..4365347 | - | 1200 | WP_054615742.1 | c-type cytochrome biogenesis protein CcmI | - |
| NK667_RS19045 (NK667_19045) | 4365344..4365814 | - | 471 | WP_054049393.1 | cytochrome c-type biogenesis protein CcmH | - |
| NK667_RS19050 (NK667_19050) | 4365811..4366347 | - | 537 | WP_054615743.1 | DsbE family thiol:disulfide interchange protein | - |
| NK667_RS19055 (NK667_19055) | 4366344..4368332 | - | 1989 | WP_054049389.1 | heme lyase CcmF/NrfE family subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21733.84 Da Isoelectric Point: 6.0970
>T251443 WP_054615741.1 NZ_CP101125:4362996-4363571 [Pseudomonas nunensis]
VRHSPFTAVYDACVLYPAPLRDFLMWLALSGRFRARWSLEIHNEWKRNLLKNRPDLTTEQLDRTSELMDQAIPDANVSGY
EDLIQGLTLPDMNDRHVLAAAIRCNASVIVTFNQKDFPCTSLEPFGVEAQHPDKFVDNLFDLDPAAVVGAAQRQRKQLKM
PSMDVSTYLDLLSRQGLVRSVEALTNYRTIL
VRHSPFTAVYDACVLYPAPLRDFLMWLALSGRFRARWSLEIHNEWKRNLLKNRPDLTTEQLDRTSELMDQAIPDANVSGY
EDLIQGLTLPDMNDRHVLAAAIRCNASVIVTFNQKDFPCTSLEPFGVEAQHPDKFVDNLFDLDPAAVVGAAQRQRKQLKM
PSMDVSTYLDLLSRQGLVRSVEALTNYRTIL
Download Length: 576 bp
Antitoxin
Download Length: 156 a.a. Molecular weight: 17304.74 Da Isoelectric Point: 6.2258
>AT251443 WP_054049618.1 NZ_CP101125:4362532-4362999 [Pseudomonas nunensis]
MSLVIHPPINLPIAREVQAAIEGQRALSAYLATQFETQRIQIFDEQNEAHNVELPTSALRLLVDILAALAEGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFADLMDYKNRRDTASEQAMTLLAEQAQALRTGYE
MSLVIHPPINLPIAREVQAAIEGQRALSAYLATQFETQRIQIFDEQNEAHNVELPTSALRLLVDILAALAEGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFADLMDYKNRRDTASEQAMTLLAEQAQALRTGYE
Download Length: 468 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|