Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1369659..1370277 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YE105_RS06050 Protein ID WP_002208622.1
Coordinates 1369659..1369862 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag YE105_RS06055 Protein ID WP_005163463.1
Coordinates 1369909..1370277 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS06025 1365030..1365368 + 339 WP_002208627.1 P-II family nitrogen regulator -
YE105_RS06030 1365408..1366697 + 1290 WP_032904831.1 ammonium transporter AmtB -
YE105_RS06035 1366811..1367674 - 864 WP_005163474.1 acyl-CoA thioesterase II -
YE105_RS06040 1367935..1368465 + 531 WP_005163468.1 YbaY family lipoprotein -
YE105_RS06045 1368517..1368822 - 306 WP_005163466.1 MGMT family protein -
YE105_RS06050 1369659..1369862 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
YE105_RS06055 1369909..1370277 - 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
YE105_RS06060 1370435..1370788 - 354 WP_005163460.1 hypothetical protein -
YE105_RS06065 1371554..1372264 + 711 WP_013649453.1 ABC transporter ATP-binding protein -
YE105_RS06070 1372278..1373123 + 846 WP_013649454.1 metal ABC transporter permease -
YE105_RS06075 1373186..1374064 + 879 WP_013649455.1 metal ABC transporter substrate-binding protein -
YE105_RS06080 1374192..1374335 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YE105_RS06085 1374351..1374611 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T25144 WP_002208622.1 NC_015224:c1369862-1369659 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T25144 NC_015224:c1369862-1369659 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT25144 WP_005163463.1 NC_015224:c1370277-1369909 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT25144 NC_015224:c1370277-1369909 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGCAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References