251437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2030960..2031474 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NMK49_RS09900 Protein ID WP_000581792.1
Coordinates 2030960..2031169 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NMK49_RS09905 Protein ID WP_000138932.1
Coordinates 2031181..2031474 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS09880 2026468..2027826 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NMK49_RS09885 2027841..2028911 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NMK49_RS09890 2029229..2030431 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NMK49_RS09895 2030695..2030832 - 138 WP_000828354.1 Lmo0850 family protein -
NMK49_RS09900 2030960..2031169 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NMK49_RS09905 2031181..2031474 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NMK49_RS09910 2031640..2033124 + 1485 WP_000571549.1 cardiolipin synthase -
NMK49_RS09915 2033152..2033799 + 648 WP_001187629.1 HD domain-containing protein -
NMK49_RS09920 2034612..2035484 - 873 WP_000725802.1 membrane protein insertase YidC -
NMK49_RS09925 2035570..2036211 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T251437 WP_000581792.1 NZ_CP101124:c2031169-2030960 [Staphylococcus aureus subsp. aureus RN4220]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT251437 WP_000138932.1 NZ_CP101124:c2031474-2031181 [Staphylococcus aureus subsp. aureus RN4220]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References