251436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2011203..2011732 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NMK49_RS09810 Protein ID WP_000621175.1
Coordinates 2011203..2011565 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NMK49_RS09815 Protein ID WP_000948331.1
Coordinates 2011562..2011732 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS09790 2008193..2008963 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
NMK49_RS09795 2008938..2009417 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NMK49_RS09800 2009419..2009745 - 327 WP_001052491.1 anti-sigma factor antagonist -
NMK49_RS09805 2009864..2010854 - 991 Protein_1887 PP2C family protein-serine/threonine phosphatase -
NMK49_RS09810 2011203..2011565 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMK49_RS09815 2011562..2011732 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NMK49_RS09820 2011817..2012965 - 1149 WP_001281145.1 alanine racemase -
NMK49_RS09825 2013031..2013390 - 360 WP_000581200.1 holo-ACP synthase -
NMK49_RS09830 2013394..2013885 - 492 WP_001205910.1 PH domain-containing protein -
NMK49_RS09835 2013872..2015455 - 1584 WP_001294626.1 PH domain-containing protein -
NMK49_RS09840 2015448..2015927 - 480 WP_001287088.1 hypothetical protein -
NMK49_RS09845 2016136..2016696 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T251436 WP_000621175.1 NZ_CP101124:c2011565-2011203 [Staphylococcus aureus subsp. aureus RN4220]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT251436 WP_000948331.1 NZ_CP101124:c2011732-2011562 [Staphylococcus aureus subsp. aureus RN4220]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References