251435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1853256..1854032 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NMK49_RS08895 Protein ID WP_000031108.1
Coordinates 1853256..1853408 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NMK49_RS08900 Protein ID WP_001251224.1
Coordinates 1853433..1854032 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS08880 1849219..1850040 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NMK49_RS08885 1850503..1851888 - 1386 WP_000116224.1 class II fumarate hydratase -
NMK49_RS08890 1852084..1852479 - 396 WP_000901021.1 hypothetical protein -
NMK49_RS08895 1853256..1853408 - 153 WP_000031108.1 SAS053 family protein Toxin
NMK49_RS08900 1853433..1854032 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NMK49_RS08905 1854191..1854661 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NMK49_RS08910 1854666..1855793 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
NMK49_RS08915 1855944..1856666 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NMK49_RS08920 1856659..1858116 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1805915..1861130 55215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T251435 WP_000031108.1 NZ_CP101124:c1853408-1853256 [Staphylococcus aureus subsp. aureus RN4220]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT251435 WP_001251224.1 NZ_CP101124:c1854032-1853433 [Staphylococcus aureus subsp. aureus RN4220]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References