Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2801308..2801822 Replicon chromosome
Accession NZ_CP101123
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag NLA26_RS13950 Protein ID WP_000581791.1
Coordinates 2801613..2801822 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag NLA26_RS13945 Protein ID WP_000138934.1
Coordinates 2801308..2801601 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA26_RS13925 (2796771) 2796771..2797412 + 642 WP_000483150.1 thiamine phosphate synthase -
NLA26_RS13930 (2797498) 2797498..2798370 + 873 WP_000725802.1 membrane protein insertase YidC -
NLA26_RS13935 (2798983) 2798983..2799630 - 648 WP_001187612.1 HD domain-containing protein -
NLA26_RS13940 (2799658) 2799658..2801142 - 1485 WP_000571560.1 cardiolipin synthase -
NLA26_RS13945 (2801308) 2801308..2801601 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
NLA26_RS13950 (2801613) 2801613..2801822 + 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
NLA26_RS13955 (2801950) 2801950..2802087 + 138 WP_000828354.1 Lmo0850 family protein -
NLA26_RS13960 (2802499) 2802499..2803182 + 684 Protein_2714 transposase -
NLA26_RS13965 (2803343) 2803343..2804545 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NLA26_RS13970 (2804863) 2804863..2805933 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T251430 WP_000581791.1 NZ_CP101123:2801613-2801822 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT251430 WP_000138934.1 NZ_CP101123:2801308-2801601 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References