Detailed information of TA system TA025142

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1042829..1043501
• Replicon: chromosome
• Accession: NC_015224
• Organism: Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7U7FIQ4
• Locus tag: YE105_RS04605
• Protein ID: WP_005166047.1
• Coordinates: 1043076..1043501 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: YE105_RS04600
• Protein ID: WP_013649338.1
• Coordinates: 1042829..1043095 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE105_RS04580	1038426..1039028	-	603	WP_013649335.1	HD domain-containing protein	-
YE105_RS04585	1039259..1039942	+	684	WP_013649336.1	hemolysin III family protein	-
YE105_RS04590	1040355..1041374	-	1020	WP_032904244.1	IS110 family transposase	-
YE105_RS04595	1041570..1042562	-	993	WP_005166051.1	tRNA-modifying protein YgfZ	-
YE105_RS04600	1042829..1043095	+	267	WP_013649338.1	FAD assembly factor SdhE	Antitoxin
YE105_RS04605	1043076..1043501	+	426	WP_005166047.1	protein YgfX	Toxin
YE105_RS04610	1043501..1044199	+	699	WP_005166045.1	two-component system response regulator CreB	-
YE105_RS04615	1044210..1045637	+	1428	WP_013649340.1	two-component system sensor histidine kinase CreC	-
YE105_RS04620	1045729..1047150	+	1422	WP_013649341.1	cell envelope integrity protein CreD	-
YE105_RS04625	1047209..1047727	-	519	WP_005166042.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1040355..1041374	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16425.21 Da
• Isoelectric Point: 9.8217

>T25142 WP_005166047.1 NC_015224:1043076-1043501 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T25142 NC_015224:1043076-1043501 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCACTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.06 Da
• Isoelectric Point: 5.1405

>AT25142 WP_013649338.1 NC_015224:1042829-1043095 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KVRGPVAM

Nucleotide

• Length: 267 bp

>AT25142 NC_015224:1042829-1043095 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGTCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FIQ4