Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 165559..166335 Replicon chromosome
Accession NZ_CP101123
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NLA26_RS01120 Protein ID WP_000031108.1
Coordinates 166183..166335 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag NLA26_RS01115 Protein ID WP_001251219.1
Coordinates 165559..166158 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA26_RS01095 (161475) 161475..162932 + 1458 WP_000649896.1 ABC transporter permease subunit -
NLA26_RS01100 (162925) 162925..163647 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NLA26_RS01105 (163798) 163798..164925 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NLA26_RS01110 (164930) 164930..165400 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NLA26_RS01115 (165559) 165559..166158 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
NLA26_RS01120 (166183) 166183..166335 + 153 WP_000031108.1 SAS053 family protein Toxin
NLA26_RS01125 (166936) 166936..167331 + 396 WP_000901019.1 hypothetical protein -
NLA26_RS01130 (167527) 167527..168912 + 1386 WP_000116227.1 class II fumarate hydratase -
NLA26_RS01135 (169368) 169368..170189 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T251419 WP_000031108.1 NZ_CP101123:166183-166335 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT251419 WP_001251219.1 NZ_CP101123:165559-166158 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References