251413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1796499..1798129 Replicon chromosome
Accession NZ_CP101115
Organism Acinetobacter sp. Z1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NGC85_RS08335 Protein ID WP_254730127.1
Coordinates 1796499..1797830 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NGC85_RS08340 Protein ID WP_254730130.1
Coordinates 1797827..1798129 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGC85_RS08310 (NGC85_08310) 1792247..1792918 - 672 WP_254730113.1 CoA transferase subunit B -
NGC85_RS08315 (NGC85_08315) 1792920..1793624 - 705 WP_254730116.1 CoA transferase subunit A -
NGC85_RS08320 (NGC85_08320) 1793855..1794736 - 882 WP_254730119.1 LysR family transcriptional regulator -
NGC85_RS08325 (NGC85_08325) 1794913..1795344 - 432 WP_254730122.1 SRPBCC family protein -
NGC85_RS08330 (NGC85_08330) 1795551..1796255 - 705 WP_254730124.1 DUF1826 domain-containing protein -
NGC85_RS08335 (NGC85_08335) 1796499..1797830 + 1332 WP_254730127.1 HipA domain-containing protein Toxin
NGC85_RS08340 (NGC85_08340) 1797827..1798129 + 303 WP_254730130.1 helix-turn-helix domain-containing protein Antitoxin
NGC85_RS08345 (NGC85_08345) 1798156..1798392 - 237 WP_254730133.1 VF530 family protein -
NGC85_RS08350 (NGC85_08350) 1798673..1798954 - 282 WP_254730136.1 hypothetical protein -
NGC85_RS08355 (NGC85_08355) 1798954..1799151 - 198 WP_070075884.1 hypothetical protein -
NGC85_RS08360 (NGC85_08360) 1799258..1799506 + 249 WP_254730139.1 hypothetical protein -
NGC85_RS08365 (NGC85_08365) 1799506..1801017 + 1512 WP_254730142.1 replication initiation factor domain-containing protein -
NGC85_RS08370 (NGC85_08370) 1801007..1801300 + 294 WP_254730145.1 hypothetical protein -
NGC85_RS08375 (NGC85_08375) 1801862..1802110 + 249 WP_254730148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50596.49 Da        Isoelectric Point: 5.1169

>T251413 WP_254730127.1 NZ_CP101115:1796499-1797830 [Acinetobacter sp. Z1]
MKKLTIQALLDQNWLDIAELTLLEPKLGSASISELAYELEYAIHNLDKRDENACSLSLPVQILIKHEASSWFGFLDDIVP
SGAARRYWVNFLGLQRLNHAEQDSILLEKGGIAPVGNLRVKEALPPINPESTLHLRYFSQADVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRSTKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRAEIDCNILRAEYYFYQELNELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQQWHRHGLESVYSVLNKASGSYLNHFEVIKNLCDLLTLIDSEFDSAQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWVKITQKLAHLCDPNLSLTTLK
SLASNLVGLKQRLIDKGVPKQIIEMPALSFNYVEAKLERWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11495.41 Da        Isoelectric Point: 9.7813

>AT251413 WP_254730130.1 NZ_CP101115:1797827-1798129 [Acinetobacter sp. Z1]
MNMNNPTQDRQQVLIDLYMQYLFNEITLGQLLAYLRKNILGLSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKD

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References