Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 609147..609674 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name relE Uniprot ID A0A7T9XW08
Locus tag YE105_RS02770 Protein ID WP_005166250.1
Coordinates 609399..609674 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7T9XW39
Locus tag YE105_RS02765 Protein ID WP_005166251.1
Coordinates 609147..609395 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS02740 605746..606840 + 1095 WP_005166255.1 LPS export ABC transporter permease LptF -
YE105_RS02745 606840..607910 + 1071 WP_005166254.1 LPS export ABC transporter permease LptG -
YE105_RS22605 608207..608716 - 510 Protein_513 helix-turn-helix domain containing protein -
YE105_RS02760 608777..609070 + 294 Protein_514 DUF4942 domain-containing protein -
YE105_RS02765 609147..609395 + 249 WP_005166251.1 ribbon-helix-helix domain-containing protein Antitoxin
YE105_RS02770 609399..609674 + 276 WP_005166250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YE105_RS02775 609793..610581 + 789 WP_005166249.1 helix-turn-helix domain-containing protein -
YE105_RS21250 610807..612019 + 1213 Protein_518 IS3 family transposase -
YE105_RS02790 612315..613040 - 726 WP_013649170.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
YE105_RS02795 613027..614535 - 1509 WP_005180650.1 IS21-like element ISYen2A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10974.31 Da        Isoelectric Point: 4.5486

>T25141 WP_005166250.1 NC_015224:609399-609674 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MEIYWTLKAQDDLERIYCFALQYSRQHGDDVLDRLITGCAGLTAYPAIGVQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T25141 NC_015224:609399-609674 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACTGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGGCGATGACGTTTTGGATCGCCTGATTACAGGCTGTGCTGGTCTTACAGCGTATCCGGCAATTGGCGTACAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTATGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.30 Da        Isoelectric Point: 6.4624

>AT25141 WP_005166251.1 NC_015224:609147-609395 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MGSLTKQTISAQIPVELATAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
QS

Download         Length: 249 bp

>AT25141 NC_015224:609147-609395 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGGTTCGCTTACTAAACAAACTATCAGCGCACAGATACCTGTTGAGTTGGCTACTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGTTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTCGCGGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTAGATTTTGCTAATCGCTTAAAG
CAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XW08

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9XW39

References