Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3872375..3873031 Replicon chromosome
Accession NZ_CP100765
Organism Serratia nematodiphila strain SASK3000

Toxin (Protein)


Gene name vapC Uniprot ID A0A086GBH4
Locus tag NLX84_RS18415 Protein ID WP_033632382.1
Coordinates 3872375..3872764 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086GBH3
Locus tag NLX84_RS18420 Protein ID WP_033632381.1
Coordinates 3872768..3873031 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX84_RS18400 (NLX84_18400) 3868842..3870272 + 1431 WP_033632384.1 multidrug transporter subunit MdtD -
NLX84_RS18405 (NLX84_18405) 3870269..3871651 + 1383 WP_033632383.1 two-component system sensor histidine kinase BaeS -
NLX84_RS18410 (NLX84_18410) 3871651..3872367 + 717 WP_004941568.1 two-component system response regulator BaeR -
NLX84_RS18415 (NLX84_18415) 3872375..3872764 - 390 WP_033632382.1 type II toxin-antitoxin system VapC family toxin Toxin
NLX84_RS18420 (NLX84_18420) 3872768..3873031 - 264 WP_033632381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NLX84_RS18425 (NLX84_18425) 3873369..3873707 + 339 WP_004941561.1 YegP family protein -
NLX84_RS18430 (NLX84_18430) 3873886..3875238 + 1353 WP_060560045.1 tRNA 5-hydroxyuridine modification protein YegQ -
NLX84_RS18435 (NLX84_18435) 3875706..3876611 + 906 WP_135638495.1 lipid kinase YegS -
NLX84_RS18440 (NLX84_18440) 3876872..3877921 + 1050 WP_015378749.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14353.58 Da        Isoelectric Point: 8.4983

>T251401 WP_033632382.1 NZ_CP100765:c3872764-3872375 [Serratia nematodiphila]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10089.34 Da        Isoelectric Point: 4.6702

>AT251401 WP_033632381.1 NZ_CP100765:c3873031-3872768 [Serratia nematodiphila]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086GBH4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GBH3

References