Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 574792..575327 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7FI46
Locus tag YE105_RS02595 Protein ID WP_005156226.1
Coordinates 575040..575327 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag YE105_RS02590 Protein ID WP_005156229.1
Coordinates 574792..575043 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS02565 570009..570893 + 885 WP_005156239.1 sugar ABC transporter permease -
YE105_RS02570 570912..571751 + 840 WP_005156238.1 carbohydrate ABC transporter permease -
YE105_RS02575 571763..572878 + 1116 WP_005156237.1 ABC transporter ATP-binding protein -
YE105_RS02580 572892..574058 + 1167 WP_013649156.1 alginate lyase family protein -
YE105_RS02585 574132..574584 + 453 WP_005181269.1 YhbP family protein -
YE105_RS02590 574792..575043 + 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
YE105_RS02595 575040..575327 + 288 WP_005156226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YE105_RS02600 575403..576032 + 630 WP_005175332.1 hypothetical protein -
YE105_RS02605 576033..576800 - 768 WP_005156220.1 phosphonate metabolism protein PhnP -
YE105_RS02610 576791..577369 - 579 WP_013649157.1 ribose 1,5-bisphosphokinase -
YE105_RS02615 577369..578517 - 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
YE105_RS02620 578514..579248 - 735 WP_032904377.1 phosphonate C-P lyase system protein PhnL -
YE105_RS02625 579262..580068 - 807 WP_013649159.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11002.07 Da        Isoelectric Point: 10.3544

>T25140 WP_005156226.1 NC_015224:575040-575327 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MIYKVKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T25140 NC_015224:575040-575327 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGATTTATAAAGTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT25140 WP_005156229.1 NC_015224:574792-575043 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT25140 NC_015224:574792-575043 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FI46

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References