Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1622881..1623434 Replicon chromosome
Accession NZ_CP100765
Organism Serratia nematodiphila strain SASK3000

Toxin (Protein)


Gene name ccdB Uniprot ID A0A086G3V8
Locus tag NLX84_RS07710 Protein ID WP_033633716.1
Coordinates 1623126..1623434 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag NLX84_RS07705 Protein ID WP_135637970.1
Coordinates 1622881..1623123 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX84_RS07690 (NLX84_07690) 1619373..1620908 + 1536 WP_004938996.1 glutathione ABC transporter substrate-binding protein GsiB -
NLX84_RS07695 (NLX84_07695) 1620961..1621881 + 921 WP_049241281.1 glutathione ABC transporter permease GsiC -
NLX84_RS07700 (NLX84_07700) 1621891..1622799 + 909 WP_174262909.1 glutathione ABC transporter permease GsiD -
NLX84_RS07705 (NLX84_07705) 1622881..1623123 + 243 WP_135637970.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NLX84_RS07710 (NLX84_07710) 1623126..1623434 + 309 WP_033633716.1 CcdB family protein Toxin
NLX84_RS07715 (NLX84_07715) 1623471..1624313 - 843 WP_048322602.1 S-formylglutathione hydrolase -
NLX84_RS07720 (NLX84_07720) 1624328..1625452 - 1125 WP_164122942.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
NLX84_RS07725 (NLX84_07725) 1625482..1626402 - 921 WP_004938975.1 LysR family transcriptional regulator -
NLX84_RS07730 (NLX84_07730) 1626508..1627665 + 1158 WP_004938972.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T251392 WP_033633716.1 NZ_CP100765:1623126-1623434 [Serratia nematodiphila]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9284.36 Da        Isoelectric Point: 4.5881

>AT251392 WP_135637970.1 NZ_CP100765:1622881-1623123 [Serratia nematodiphila]
MDMANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWRDQNREALEELNRITEENGLLSDEYRTF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G3V8

Antitoxin

Source ID Structure

References