Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3216284..3216909 Replicon chromosome
Accession NZ_CP100764
Organism Serratia plymuthica strain SASK2000

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U3Z353
Locus tag NLX81_RS15345 Protein ID WP_013813456.1
Coordinates 3216284..3216466 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4DXE6
Locus tag NLX81_RS15350 Protein ID WP_013813457.1
Coordinates 3216496..3216909 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX81_RS15340 (NLX81_15340) 3212146..3216117 + 3972 Protein_2996 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
NLX81_RS15345 (NLX81_15345) 3216284..3216466 + 183 WP_013813456.1 type II toxin-antitoxin system HicA family toxin Toxin
NLX81_RS15350 (NLX81_15350) 3216496..3216909 + 414 WP_013813457.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLX81_RS15355 (NLX81_15355) 3216942..3217694 - 753 WP_013813458.1 L-cystine ABC transporter ATP-binding protein TcyN -
NLX81_RS15360 (NLX81_15360) 3217698..3218360 - 663 WP_013813459.1 cystine ABC transporter permease -
NLX81_RS15365 (NLX81_15365) 3218360..3219160 - 801 WP_013813460.1 cystine ABC transporter substrate-binding protein -
NLX81_RS15370 (NLX81_15370) 3219275..3220267 - 993 WP_013813461.1 D-cysteine desulfhydrase -
NLX81_RS15375 (NLX81_15375) 3220393..3220902 - 510 WP_013813462.1 flagella biosynthesis regulatory protein FliZ -
NLX81_RS15380 (NLX81_15380) 3220959..3221681 - 723 WP_013813463.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6992.28 Da        Isoelectric Point: 11.3081

>T251385 WP_013813456.1 NZ_CP100764:3216284-3216466 [Serratia plymuthica]
VKSSELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15038.71 Da        Isoelectric Point: 4.6961

>AT251385 WP_013813457.1 NZ_CP100764:3216496-3216909 [Serratia plymuthica]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELSKAG

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z353

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4DXE6

References