Detailed information of TA system TA025138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1646786..1647305
• Accession: NC_015215
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F5WVW3
• Locus tag: SGGBAA2069_RS08210
• Protein ID: WP_012962242.1
• Coordinates: 1646786..1647064 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F5WVW4
• Locus tag: SGGBAA2069_RS08215
• Protein ID: WP_012962243.1
• Coordinates: 1647057..1647305 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGGBAA2069_RS08180	1642103..1642711	-	609	WP_009854651.1	TVP38/TMEM64 family protein	-
SGGBAA2069_RS08190	1642959..1643261	-	303	WP_013643299.1	PepSY domain-containing protein	-
SGGBAA2069_RS08195	1643504..1645036	-	1533	WP_013643300.1	HAMP domain-containing histidine kinase	-
SGGBAA2069_RS08200	1644981..1645673	-	693	WP_012962240.1	response regulator transcription factor	-
SGGBAA2069_RS08205	1645779..1646657	-	879	WP_013643301.1	DUF3114 domain-containing protein	-
SGGBAA2069_RS08210	1646786..1647064	-	279	WP_012962242.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SGGBAA2069_RS08215	1647057..1647305	-	249	WP_012962243.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SGGBAA2069_RS08220	1647633..1648151	+	519	WP_009854658.1	TetR/AcrR family transcriptional regulator	-
SGGBAA2069_RS08225	1648265..1650034	+	1770	WP_009854659.1	oleate hydratase	-
SGGBAA2069_RS08230	1650167..1650991	-	825	WP_043910976.1	class C sortase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11043.84 Da
• Isoelectric Point: 9.3104

>T25138 WP_012962242.1 NC_015215:c1647064-1646786 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MLKIKYHRQFKRDYKLALKRGLKASKLEEVLEILIKGESLPEKYRDHQLVASKYYQNVRECHIQPDWLLIYQIDDDNLIL
NLVRTGSHSDLF

Nucleotide

• Length: 279 bp

>T25138 NC_015215:c1647064-1646786 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGCTTAAAATTAAATACCACAGACAGTTTAAAAGGGATTATAAACTAGCTTTAAAACGTGGTTTAAAAGCTTCCAAACT
AGAGGAAGTCTTAGAAATTTTAATAAAGGGTGAAAGTTTACCAGAAAAATATAGAGACCACCAACTAGTGGCAAGTAAAT
ATTATCAAAATGTTAGAGAATGTCATATTCAGCCTGATTGGTTATTAATTTATCAGATTGATGATGATAATTTGATTTTG
AATTTAGTGCGAACGGGTAGTCATTCGGATTTATTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9204.69 Da
• Isoelectric Point: 4.3193

>AT25138 WP_012962243.1 NC_015215:c1647305-1647057 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MTTITFKVDDEMKKEATELYKSMGLDLSSALRLFIKQSLVTRSIPFVIKADELTPVLDDVVKGVNMSEEFTDVKSLMESL
DA

Nucleotide

• Length: 249 bp

>AT25138 NC_015215:c1647305-1647057 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGACTACAATTACATTTAAAGTTGATGATGAAATGAAAAAGGAAGCAACTGAACTTTATAAATCAATGGGGCTAGATTT
ATCTAGTGCATTACGCTTGTTTATAAAGCAATCTCTTGTTACTCGTAGTATTCCTTTTGTTATTAAAGCTGATGAATTAA
CTCCTGTTCTTGATGATGTCGTAAAGGGTGTTAACATGAGTGAAGAATTTACTGATGTTAAAAGTTTGATGGAGAGTTTA
GATGCTTAA

Structures

Toxin

• AlphaFold DB: F5WVW3

Antitoxin

• AlphaFold DB: F5WVW4