Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1151965..1152587 Replicon chromosome
Accession NZ_CP100764
Organism Serratia plymuthica strain SASK2000

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag NLX81_RS05420 Protein ID WP_006322256.1
Coordinates 1151965..1152168 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag NLX81_RS05425 Protein ID WP_004949348.1
Coordinates 1152219..1152587 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX81_RS05410 (NLX81_05410) 1148331..1149005 - 675 WP_013811773.1 DNA N-6-adenine-methyltransferase -
NLX81_RS05415 (NLX81_05415) 1149245..1151254 - 2010 WP_013811774.1 glycosyl hydrolase family 28-related protein -
NLX81_RS05420 (NLX81_05420) 1151965..1152168 - 204 WP_006322256.1 HHA domain-containing protein Toxin
NLX81_RS05425 (NLX81_05425) 1152219..1152587 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
NLX81_RS05430 (NLX81_05430) 1152747..1153074 - 328 Protein_1043 hypothetical protein -
NLX81_RS05435 (NLX81_05435) 1153554..1154268 + 715 Protein_1044 ABC transporter ATP-binding protein -
NLX81_RS05440 (NLX81_05440) 1154265..1155122 + 858 WP_013811777.1 metal ABC transporter permease -
NLX81_RS05445 (NLX81_05445) 1155148..1156026 + 879 WP_013811778.1 metal ABC transporter substrate-binding protein -
NLX81_RS05450 (NLX81_05450) 1156142..1156282 - 141 WP_013811779.1 type B 50S ribosomal protein L36 -
NLX81_RS05455 (NLX81_05455) 1156295..1156549 - 255 WP_004949355.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1135692..1152891 17199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T251379 WP_006322256.1 NZ_CP100764:c1152168-1151965 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT251379 WP_004949348.1 NZ_CP100764:c1152587-1152219 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References