Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 555242..556791 Replicon chromosome
Accession NZ_CP100764
Organism Serratia plymuthica strain SASK2000

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U3YYG4
Locus tag NLX81_RS02625 Protein ID WP_013811338.1
Coordinates 555493..556791 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NLX81_RS02620 Protein ID WP_004953056.1
Coordinates 555242..555490 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX81_RS02590 (NLX81_02590) 550457..551527 + 1071 WP_013811333.1 LPS export ABC transporter permease LptG -
NLX81_RS02600 (NLX81_02600) 552021..552236 + 216 WP_013811334.1 hypothetical protein -
NLX81_RS02605 (NLX81_02605) 552269..552970 - 702 WP_013811335.1 hypothetical protein -
NLX81_RS02610 (NLX81_02610) 553310..553945 + 636 WP_013811336.1 carbonic anhydrase -
NLX81_RS02615 (NLX81_02615) 554375..554833 - 459 WP_013811337.1 hypothetical protein -
NLX81_RS02620 (NLX81_02620) 555242..555490 + 249 WP_004953056.1 helix-turn-helix domain-containing protein Antitoxin
NLX81_RS02625 (NLX81_02625) 555493..556791 + 1299 WP_013811338.1 type II toxin-antitoxin system HipA family toxin Toxin
NLX81_RS02630 (NLX81_02630) 556905..557155 - 251 Protein_497 hypothetical protein -
NLX81_RS02635 (NLX81_02635) 557476..560112 + 2637 WP_013811339.1 Z1 domain-containing protein -
NLX81_RS02640 (NLX81_02640) 560118..561116 + 999 WP_254754843.1 PD-(D/E)XK motif protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 555242..569776 14534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48216.28 Da        Isoelectric Point: 5.6236

>T251376 WP_013811338.1 NZ_CP100764:555493-556791 [Serratia plymuthica]
MEKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQARFK
TATKQPFDLLSSIGSDCVGAIQLYPEHADVAPVKQVNAVPVSDEEIEQLLLGYREAPLGMEAGIDDFRISLAGAQEKTAL
LWFGNQWCRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELAHFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAHALKYEADGGPGIAAAMELLLGSQQPLLDRDIFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMNARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMAELKAQTEQAI
ANVEAMLPDEFPRLVSDAIFAGVRRQAERLVG

Download         Length: 1299 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9263.60 Da        Isoelectric Point: 10.4887

>AT251376 WP_004953056.1 NZ_CP100764:555242-555490 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YYG4

Antitoxin

Source ID Structure

References