Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1312262..1313975 Replicon chromosome
Accession NZ_CP100755
Organism Alcaligenes sp. NLF5-7

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MID00_RS06200 Protein ID WP_247966080.1
Coordinates 1313055..1313975 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MID00_RS06195 Protein ID WP_083054297.1
Coordinates 1312262..1313065 (-) Length 268 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MID00_RS06175 (MID00_06175) 1307337..1308824 - 1488 WP_247966076.1 aldehyde dehydrogenase -
MID00_RS06180 (MID00_06180) 1308850..1309650 - 801 WP_083054295.1 aspartate dehydrogenase -
MID00_RS06185 (MID00_06185) 1309662..1311371 - 1710 WP_254500011.1 thiamine pyrophosphate-binding protein -
MID00_RS06190 (MID00_06190) 1311364..1312197 - 834 WP_254500013.1 SDR family oxidoreductase -
MID00_RS06195 (MID00_06195) 1312262..1313065 - 804 WP_083054297.1 IclR family transcriptional regulator Antitoxin
MID00_RS06200 (MID00_06200) 1313055..1313975 - 921 WP_247966080.1 alpha/beta hydrolase Toxin
MID00_RS06205 (MID00_06205) 1314001..1314534 - 534 WP_026484076.1 cupin domain-containing protein -
MID00_RS06210 (MID00_06210) 1314559..1315371 - 813 WP_254500014.1 SDR family oxidoreductase -
MID00_RS06215 (MID00_06215) 1315636..1317171 - 1536 WP_009462680.1 3-hydroxyacyl-CoA dehydrogenase -
MID00_RS06220 (MID00_06220) 1317203..1318435 - 1233 WP_254500016.1 CaiB/BaiF CoA-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-280)

Antitoxin

Transcription regulator IclR, N-terminal

(19-69)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 33195.16 Da        Isoelectric Point: 6.5748

>T251370 WP_247966080.1 NZ_CP100755:c1313975-1313055 [Alcaligenes sp. NLF5-7]
MNPLPGTLPLLSARETRYLQACLPLSTVDIGRGRQVAVRCAGDGEQWVVCLHGIGSGSASWLRVAQQLPPGLRLLAWDAP
GYGLSTPLEMDKPTALDYARRLQELLHVLEVKDFVLVGHSLGALMAGAYARHLDQGEMQALFLMSPAIGYGRPGLEQRRQ
AVWDQRMAQVASGDMGLMARQRHQRLLSEQATSENRELVLWIMASLHLAGYQQAVQMLCQEDLLTYLPLSSSVPVAVSCG
EVDVVTTPEACAGVARACSQHLQLVPQAGHASYVEQPGAMLEALQSLLGQTQALRSVATTRSSHEQ

Download         Length: 921 bp

Antitoxin


Download         Length: 268 a.a.        Molecular weight: 29253.46 Da        Isoelectric Point: 5.7053

>AT251370 WP_083054297.1 NZ_CP100755:c1313065-1312262 [Alcaligenes sp. NLF5-7]
MSSELNKSDASADRYTVPALERGLLILTQFSRDQRTLGAPELARRLDLPRSTVFRLLSTLEGMGFVERTENGRDYRLSVG
VLRLGFEYVASLDVTELGRPVMERLCEQVRLPCNLVVRDLRSIVYVSRIAAPTPFASSVTVGTRLPAHATVLGHVLLSQL
SLTELKELYPEPELERFTSHTPADVPQLYEFCQAIREQGYALSEGYFESTISTIAAPVFNGAGKVAAALGVTAMAASFEG
ERLAEMIAQVKAAAAELSELVRHSPHS

Download         Length: 804 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References