Detailed information of TA system TA025137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1518370..1518950
• Accession: NC_015215
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F5WVJ0
• Locus tag: SGGBAA2069_RS07585
• Protein ID: WP_009854536.1
• Coordinates: 1518762..1518950 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SGGBAA2069_RS07580
• Protein ID: WP_009854535.1
• Coordinates: 1518370..1518750 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.25 Da
• Isoelectric Point: 10.8207

>T25137 WP_009854536.1 NC_015215:c1518950-1518762 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Nucleotide

• Length: 189 bp

>T25137 NC_015215:c1518950-1518762 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
GTGCCGTTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACAATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14141.02 Da
• Isoelectric Point: 4.2393

>AT25137 WP_009854535.1 NC_015215:c1518750-1518370 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVNMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADRENVNYSEVLTQALEKKLQL

Nucleotide

• Length: 381 bp

>AT25137 NC_015215:c1518750-1518370 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGATGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATCTAGATG
AAGGTTTAGAGCTTCCAAAGGTTGTTAATATGAGTGAATTATCAGTTGAAGATGGTTTTATCACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAATGTTACTGTTCCAGAATGGTTAGTCAGATTAGCAGACCG
TGAGAATGTGAATTACTCGGAGGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Structures

Toxin

• AlphaFold DB: A0A1S5WDX8