Detailed information of TA system TA025137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1518370..1518950
• Accession: NC_015215
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F5WVJ0
• Locus tag: SGGBAA2069_RS07585
• Protein ID: WP_009854536.1
• Coordinates: 1518762..1518950 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SGGBAA2069_RS07580
• Protein ID: WP_009854535.1
• Coordinates: 1518370..1518750 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGGBAA2069_RS07570	1513722..1515557	-	1836	WP_003065532.1	translation elongation factor 4	-
SGGBAA2069_RS07575	1516654..1517070	-	417	WP_009854531.1	nucleoside-diphosphate kinase	-
SGGBAA2069_RS07580	1518370..1518750	-	381	WP_009854535.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SGGBAA2069_RS07585	1518762..1518950	-	189	WP_009854536.1	type II toxin-antitoxin system HicA family toxin	Toxin
SGGBAA2069_RS07590	1519046..1519711	-	666	WP_172855736.1	type II-A CRISPR-associated protein Csn2	-
SGGBAA2069_RS07595	1519698..1520042	-	345	WP_009854538.1	CRISPR-associated endonuclease Cas2	-
SGGBAA2069_RS07600	1520039..1520905	-	867	WP_009854539.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.25 Da
• Isoelectric Point: 10.8207

>T25137 WP_009854536.1 NC_015215:c1518950-1518762 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Nucleotide

• Length: 189 bp

>T25137 NC_015215:c1518950-1518762 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
GTGCCGTTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACAATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14141.02 Da
• Isoelectric Point: 4.2393

>AT25137 WP_009854535.1 NC_015215:c1518750-1518370 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVNMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADRENVNYSEVLTQALEKKLQL

Nucleotide

• Length: 381 bp

>AT25137 NC_015215:c1518750-1518370 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGATGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATCTAGATG
AAGGTTTAGAGCTTCCAAAGGTTGTTAATATGAGTGAATTATCAGTTGAAGATGGTTTTATCACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAATGTTACTGTTCCAGAATGGTTAGTCAGATTAGCAGACCG
TGAGAATGTGAATTACTCGGAGGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Structures

Toxin

• AlphaFold DB: A0A1S5WDX8