Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5095912..5096648 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLX77_RS24360 Protein ID WP_076741273.1
Coordinates 5095912..5096391 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7DAD3
Locus tag NLX77_RS24365 Protein ID WP_015379309.1
Coordinates 5096388..5096648 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS24335 (NLX77_24335) 5091559..5092032 - 474 WP_004930745.1 transcription elongation factor GreB -
NLX77_RS24340 (NLX77_24340) 5092262..5093224 + 963 WP_118892666.1 curved DNA-binding protein -
NLX77_RS24345 (NLX77_24345) 5093230..5093535 + 306 WP_004930739.1 chaperone modulator CbpM -
NLX77_RS24350 (NLX77_24350) 5093793..5094512 + 720 WP_004709363.1 two-component system response regulator OmpR -
NLX77_RS24355 (NLX77_24355) 5094509..5095879 + 1371 WP_015379311.1 two-component system sensor histidine kinase EnvZ -
NLX77_RS24360 (NLX77_24360) 5095912..5096391 - 480 WP_076741273.1 type II toxin-antitoxin system VapC family toxin Toxin
NLX77_RS24365 (NLX77_24365) 5096388..5096648 - 261 WP_015379309.1 plasmid stability-like protein Antitoxin
NLX77_RS24370 (NLX77_24370) 5096776..5098395 - 1620 WP_254520036.1 phosphoenolpyruvate carboxykinase (ATP) -
NLX77_RS24375 (NLX77_24375) 5098590..5099468 - 879 WP_015379307.1 Hsp33 family molecular chaperone HslO -
NLX77_RS24380 (NLX77_24380) 5099494..5099901 - 408 WP_015379306.1 ribosome-associated heat shock protein Hsp15 -
NLX77_RS24385 (NLX77_24385) 5099898..5100578 - 681 WP_004930298.1 GMP/IMP nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 18028.66 Da        Isoelectric Point: 5.9070

>T251368 WP_076741273.1 NZ_CP100753:c5096391-5095912 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGATLATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9907.29 Da        Isoelectric Point: 5.1898

>AT251368 WP_015379309.1 NZ_CP100753:c5096648-5096388 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DAD3

References