Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3176633..3177180 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1Q4P6P4
Locus tag NLX77_RS15255 Protein ID WP_073528876.1
Coordinates 3176633..3176941 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag NLX77_RS15260 Protein ID WP_033633717.1
Coordinates 3176944..3177180 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS15235 (NLX77_15235) 3172402..3173559 - 1158 WP_004938972.1 YbfB/YjiJ family MFS transporter -
NLX77_RS15240 (NLX77_15240) 3173665..3174585 + 921 WP_118892277.1 LysR family transcriptional regulator -
NLX77_RS15245 (NLX77_15245) 3174615..3175739 + 1125 WP_015377215.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
NLX77_RS15250 (NLX77_15250) 3175754..3176596 + 843 WP_118892278.1 S-formylglutathione hydrolase -
NLX77_RS15255 (NLX77_15255) 3176633..3176941 - 309 WP_073528876.1 CcdB family protein Toxin
NLX77_RS15260 (NLX77_15260) 3176944..3177180 - 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NLX77_RS15265 (NLX77_15265) 3177268..3178176 - 909 WP_254519799.1 glutathione ABC transporter permease GsiD -
NLX77_RS15270 (NLX77_15270) 3178186..3179106 - 921 WP_004938995.1 glutathione ABC transporter permease GsiC -
NLX77_RS15275 (NLX77_15275) 3179159..3180694 - 1536 WP_118892279.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T251366 WP_073528876.1 NZ_CP100753:c3176941-3176633 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT251366 WP_033633717.1 NZ_CP100753:c3177180-3176944 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4P6P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References