Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3047056..3047581 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NLX77_RS14695 Protein ID WP_015377296.1
Coordinates 3047297..3047581 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag NLX77_RS14690 Protein ID WP_004928423.1
Coordinates 3047056..3047307 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS14660 (NLX77_14660) 3042330..3042872 + 543 WP_015377301.1 lipoprotein -
NLX77_RS14665 (NLX77_14665) 3043135..3043863 + 729 WP_004928406.1 arginine ABC transporter ATP-binding protein ArtP -
NLX77_RS14670 (NLX77_14670) 3043896..3044627 + 732 WP_004928409.1 arginine ABC transporter substrate-binding protein -
NLX77_RS14675 (NLX77_14675) 3044637..3045353 + 717 WP_004928413.1 arginine ABC transporter permease ArtQ -
NLX77_RS14680 (NLX77_14680) 3045353..3046021 + 669 WP_015377298.1 arginine ABC transporter permease ArtM -
NLX77_RS14685 (NLX77_14685) 3046220..3046954 + 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
NLX77_RS14690 (NLX77_14690) 3047056..3047307 + 252 WP_004928423.1 prevent-host-death protein Antitoxin
NLX77_RS14695 (NLX77_14695) 3047297..3047581 + 285 WP_015377296.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX77_RS14700 (NLX77_14700) 3047578..3048705 - 1128 WP_118892261.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
NLX77_RS14705 (NLX77_14705) 3048775..3049254 - 480 WP_015377294.1 YbjO family protein -
NLX77_RS14710 (NLX77_14710) 3049359..3050204 - 846 WP_254519784.1 putrescine ABC transporter permease PotI -
NLX77_RS14715 (NLX77_14715) 3050201..3051163 - 963 WP_021504359.1 putrescine ABC transporter permease PotH -
NLX77_RS14720 (NLX77_14720) 3051188..3052321 - 1134 WP_049187444.1 putrescine ABC transporter ATP-binding subunit PotG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10803.94 Da        Isoelectric Point: 10.6941

>T251365 WP_015377296.1 NZ_CP100753:3047297-3047581 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT251365 WP_004928423.1 NZ_CP100753:3047056-3047307 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References