Detailed information of TA system TA025136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 737786..738395
• Accession: NC_015215
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SGGBAA2069_RS03845
• Protein ID: WP_013642909.1
• Coordinates: 738066..738395 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1S5WA73
• Locus tag: SGGBAA2069_RS03840
• Protein ID: WP_013642908.1
• Coordinates: 737786..738076 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGGBAA2069_RS03820	733359..734873	+	1515	WP_012961726.1	zinc ABC transporter substrate-binding protein AdcA	-
SGGBAA2069_RS03825	735084..735818	+	735	WP_012961727.1	polyphosphate polymerase domain-containing protein	-
SGGBAA2069_RS03830	735841..736533	+	693	WP_009853852.1	DUF4956 domain-containing protein	-
SGGBAA2069_RS03835	736706..737422	+	717	WP_009853856.1	glycoside hydrolase family 73 protein	-
SGGBAA2069_RS03840	737786..738076	+	291	WP_013642908.1	hypothetical protein	Antitoxin
SGGBAA2069_RS03845	738066..738395	+	330	WP_013642909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SGGBAA2069_RS03850	738699..739229	-	531	WP_013642910.1	hypothetical protein	-
SGGBAA2069_RS03855	739402..740658	-	1257	WP_013642911.1	plasmid recombination protein	-
SGGBAA2069_RS03860	740975..741409	-	435	WP_013642912.1	hypothetical protein	-
SGGBAA2069_RS03865	741596..742447	-	852	WP_013642913.1	replication initiation protein	-
SGGBAA2069_RS03870	742750..743391	-	642	WP_043913625.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	737465..745998	8533

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12585.50 Da
• Isoelectric Point: 8.3467

>T25136 WP_013642909.1 NC_015215:738066-738395 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MDYKVSYNTGALEALVEIKEYIINNFKSETSAKKVVDNIMQKISALEIFPEVGFDADERFGKTLDKRHKTRGLTIGKDYI
ALYFVNDEKKEVIITHIVSTRSDYVKLFK

Nucleotide

• Length: 330 bp

>T25136 NC_015215:738066-738395 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
TTGGATTATAAAGTGAGTTATAACACTGGTGCTTTGGAAGCATTGGTAGAAATAAAAGAATATATAATTAATAATTTCAA
GTCAGAAACATCAGCGAAAAAAGTAGTTGATAATATCATGCAAAAAATAAGTGCTTTAGAGATTTTTCCTGAAGTAGGGT
TTGATGCTGATGAAAGATTTGGAAAAACTTTAGATAAACGTCATAAAACCAGAGGTTTAACAATTGGGAAAGATTATATA
GCTTTATATTTTGTTAATGATGAAAAAAAGGAAGTTATCATTACCCATATTGTCTCAACTCGAAGTGATTATGTGAAATT
GTTCAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11015.58 Da
• Isoelectric Point: 4.9477

>AT25136 WP_013642908.1 NC_015215:737786-738076 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MVVAEKNRAVTFQANKELVSEAKEVLNKKNLTLSHALRLFLQNVVVTNEIDLLNEEELEKEKLFRQLQGEIKQAIDDYEA
GVNTYSAEEVRKRLGL

Nucleotide

• Length: 291 bp

>AT25136 NC_015215:737786-738076 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGGTAGTTGCAGAAAAAAATAGAGCCGTCACTTTTCAAGCTAATAAAGAATTAGTAAGTGAGGCTAAAGAAGTTTTAAA
TAAAAAGAATTTGACATTATCACATGCTTTAAGATTATTTTTACAAAATGTTGTTGTTACTAATGAAATTGACTTGTTGA
ACGAAGAAGAACTAGAAAAAGAGAAGTTATTTAGACAACTTCAAGGAGAAATAAAGCAGGCTATAGATGATTATGAAGCT
GGTGTAAATACTTATTCAGCTGAAGAGGTGAGAAAACGTCTTGGATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S5WA73