251353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1386720..1387636 Replicon chromosome
Accession NZ_CP100752
Organism Bacillus halotolerans strain MEC_B301

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag NLV76_RS07285 Protein ID WP_024121091.1
Coordinates 1386890..1387636 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag NLV76_RS07280 Protein ID WP_024121090.1
Coordinates 1386720..1386890 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLV76_RS07240 (NLV76_07240) 1381738..1383570 + 1833 WP_254503611.1 terminase -
NLV76_RS07245 (NLV76_07245) 1383582..1383912 + 331 Protein_1364 XkdW family protein -
NLV76_RS07250 (NLV76_07250) 1383909..1384073 + 165 WP_044156230.1 XkdX family protein -
NLV76_RS07255 (NLV76_07255) 1384117..1384956 + 840 WP_254503220.1 phage portal protein -
NLV76_RS07260 (NLV76_07260) 1385012..1385281 + 270 WP_059352787.1 hemolysin XhlA family protein -
NLV76_RS07265 (NLV76_07265) 1385293..1385556 + 264 WP_059352788.1 phage holin -
NLV76_RS07270 (NLV76_07270) 1385569..1386462 + 894 WP_254503221.1 N-acetylmuramoyl-L-alanine amidase -
NLV76_RS07275 (NLV76_07275) 1386499..1386636 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NLV76_RS07280 (NLV76_07280) 1386720..1386890 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NLV76_RS07285 (NLV76_07285) 1386890..1387636 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NLV76_RS07290 (NLV76_07290) 1387746..1388747 - 1002 WP_254503222.1 inorganic phosphate transporter -
NLV76_RS07295 (NLV76_07295) 1388760..1389377 - 618 WP_254503223.1 DUF47 domain-containing protein -
NLV76_RS07300 (NLV76_07300) 1389653..1390969 - 1317 WP_254503224.1 serine/threonine exchanger -
NLV76_RS07305 (NLV76_07305) 1391364..1392314 + 951 WP_254503225.1 ring-cleaving dioxygenase -
NLV76_RS07310 (NLV76_07310) 1392480..1392560 + 81 Protein_1377 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1353753..1396075 42322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T251353 WP_024121091.1 NZ_CP100752:c1387636-1386890 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT251353 WP_024121090.1 NZ_CP100752:c1386890-1386720 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References