25135

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 622679..623165 Replicon
Accession NC_015215
Organism Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069

Toxin (Protein)


Gene name relE Uniprot ID F5WZP9
Locus tag SGGBAA2069_RS03295 Protein ID WP_013642846.1
Coordinates 622896..623165 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5WZP8
Locus tag SGGBAA2069_RS03290 Protein ID WP_013642845.1
Coordinates 622679..622906 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGGBAA2069_RS03270 618817..619131 + 315 WP_003063779.1 metalloregulator ArsR/SmtB family transcription factor -
SGGBAA2069_RS03275 619134..621017 + 1884 WP_013642843.1 cadmium-translocating P-type ATPase -
SGGBAA2069_RS03280 621176..621496 + 321 WP_013642844.1 multidrug efflux SMR transporter -
SGGBAA2069_RS03285 621713..622405 + 693 WP_009853732.1 phosphoglycerate mutase -
SGGBAA2069_RS03290 622679..622906 + 228 WP_013642845.1 hypothetical protein Antitoxin
SGGBAA2069_RS03295 622896..623165 + 270 WP_013642846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SGGBAA2069_RS03300 623544..624110 - 567 WP_013642847.1 DUF3267 domain-containing protein -
SGGBAA2069_RS03305 624359..624880 + 522 WP_013642848.1 transcription repressor NadR -
SGGBAA2069_RS03310 625077..625631 + 555 WP_013642849.1 hypothetical protein -
SGGBAA2069_RS03315 625786..627939 + 2154 WP_013642850.1 penicillin-binding protein PBP2B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10582.65 Da        Isoelectric Point: 10.5078

>T25135 WP_013642846.1 NC_015215:622896-623165 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGRALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Download         Length: 270 bp

>T25135 NC_015215:622896-623165 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGACTTATAGATTAGTTGTTAGTGACAAGGTCAAGAAACAACTAAAGAAAATGGATAAGCATGTAAGGCTTATGCTTGC
TAAAGACATGAAGAAACACCTTGATGGTTTAGAGAACCCTAGACAAATTGGAAGAGCACTAATAGGTCAATTCAAAGGCC
TATGGCGTTACCGAATAGGAAATTATAGAGTTATTTGTGATATTATGGACGATGAATTAGTTATTCTTGCTATTGAAATC
GGACATAGAAAAGATATTTATAAAAACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8732.81 Da        Isoelectric Point: 4.3239

>AT25135 WP_013642845.1 NC_015215:622679-622906 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALKEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp

>AT25135 NC_015215:622679-622906 [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGTCAATCGTATCACTTAGACTAAATGAAAAAGAAGAAGAACTTTTTAGAAGTTATTCTATCCATACAGGAAAGACATT
ATCAGAGTTGTTTAAAACAGCTTTAGCTGAACAAATTGAAGACCAATTAGATTATGAAACAGGCATTAAAGCATTGAAAG
AATTCAAAAAGAATCCTGTTACTCACTCTATTGATGATATTATTGAGGAGTTTGAAAATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5WZP9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WAU8

References