Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4156506..4157287 Replicon chromosome
Accession NZ_CP100747
Organism Salmonella enterica subsp. enterica serovar Montevideo strain R17.4849

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag NL707_RS20365 Protein ID WP_000625912.1
Coordinates 4156506..4156997 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V5GNB3
Locus tag NL707_RS20370 Protein ID WP_001110451.1
Coordinates 4156994..4157287 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL707_RS20340 (4151637) 4151637..4154075 - 2439 WP_000016434.1 F4 (K88) fimbrial usher FaeD -
NL707_RS20345 (4154085) 4154085..4154624 - 540 WP_000721295.1 type 1 fimbrial protein -
NL707_RS20350 (4154659) 4154659..4154943 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NL707_RS20355 (4155536) 4155536..4155793 + 258 WP_001112996.1 hypothetical protein -
NL707_RS20360 (4156038) 4156038..4156271 - 234 Protein_3975 IS481 family transposase -
NL707_RS20365 (4156506) 4156506..4156997 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
NL707_RS20370 (4156994) 4156994..4157287 - 294 WP_001110451.1 DUF1778 domain-containing protein Antitoxin
NL707_RS20375 (4157605) 4157605..4157827 + 223 Protein_3978 hypothetical protein -
NL707_RS20380 (4158091) 4158091..4158966 + 876 WP_000921676.1 AraC family transcriptional regulator -
NL707_RS20385 (4158963) 4158963..4159250 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL707_RS20390 (4159243) 4159243..4159425 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
NL707_RS20395 (4159445) 4159445..4159544 + 100 Protein_3982 hypothetical protein -
NL707_RS20400 (4159654) 4159654..4159788 + 135 Protein_3983 hypothetical protein -
NL707_RS20405 (4160082) 4160082..4160987 - 906 WP_001268201.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4144885..4159425 14540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T251349 WP_000625912.1 NZ_CP100747:c4156997-4156506 [Salmonella enterica subsp. enterica serovar Montevideo]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.62 Da        Isoelectric Point: 9.8579

>AT251349 WP_001110451.1 NZ_CP100747:c4157287-4156994 [Salmonella enterica subsp. enterica serovar Montevideo]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMRTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5GNB3

References