Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4041608..4042124 Replicon chromosome
Accession NZ_CP100747
Organism Salmonella enterica subsp. enterica serovar Montevideo strain R17.4849

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NL707_RS19735 Protein ID WP_000220578.1
Coordinates 4041608..4041892 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL707_RS19740 Protein ID WP_000212724.1
Coordinates 4041882..4042124 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL707_RS19720 (4036724) 4036724..4038376 + 1653 WP_000154969.1 alpha,alpha-phosphotrehalase -
NL707_RS19725 (4038785) 4038785..4040923 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
NL707_RS19730 (4041140) 4041140..4041604 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL707_RS19735 (4041608) 4041608..4041892 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL707_RS19740 (4041882) 4041882..4042124 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL707_RS19745 (4042202) 4042202..4044115 - 1914 WP_001212153.1 BglG family transcription antiterminator -
NL707_RS19750 (4044132) 4044132..4044872 - 741 WP_000779263.1 KDGP aldolase family protein -
NL707_RS19755 (4044869) 4044869..4045987 - 1119 WP_001139174.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL707_RS19760 (4045971) 4045971..4047104 - 1134 WP_000459953.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251348 WP_000220578.1 NZ_CP100747:c4041892-4041608 [Salmonella enterica subsp. enterica serovar Montevideo]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251348 WP_000212724.1 NZ_CP100747:c4042124-4041882 [Salmonella enterica subsp. enterica serovar Montevideo]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References