Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3359743..3360363 Replicon chromosome
Accession NZ_CP100747
Organism Salmonella enterica subsp. enterica serovar Montevideo strain R17.4849

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL707_RS16630 Protein ID WP_001280991.1
Coordinates 3360145..3360363 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL707_RS16625 Protein ID WP_000344807.1
Coordinates 3359743..3360117 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL707_RS16615 (3354882) 3354882..3356075 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL707_RS16620 (3356098) 3356098..3359247 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL707_RS16625 (3359743) 3359743..3360117 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL707_RS16630 (3360145) 3360145..3360363 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL707_RS16635 (3360542) 3360542..3361093 + 552 WP_001278791.1 maltose O-acetyltransferase -
NL707_RS16640 (3361211) 3361211..3361681 + 471 WP_000136183.1 YlaC family protein -
NL707_RS16645 (3361737) 3361737..3361877 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL707_RS16650 (3361883) 3361883..3362143 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL707_RS16655 (3362368) 3362368..3363918 + 1551 WP_000213134.1 EAL domain-containing protein -
NL707_RS16665 (3364149) 3364149..3364538 + 390 WP_000961285.1 MGMT family protein -
NL707_RS16670 (3364571) 3364571..3365140 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251346 WP_001280991.1 NZ_CP100747:3360145-3360363 [Salmonella enterica subsp. enterica serovar Montevideo]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251346 WP_000344807.1 NZ_CP100747:3359743-3360117 [Salmonella enterica subsp. enterica serovar Montevideo]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References