Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1006073..1006887 Replicon chromosome
Accession NZ_CP100747
Organism Salmonella enterica subsp. enterica serovar Montevideo strain R17.4849

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL707_RS04840 Protein ID WP_000971655.1
Coordinates 1006073..1006600 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL707_RS04845 Protein ID WP_000855694.1
Coordinates 1006597..1006887 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL707_RS04815 (1002449) 1002449..1002847 + 399 Protein_942 cytoplasmic protein -
NL707_RS04820 (1003432) 1003432..1004100 + 669 WP_000445914.1 hypothetical protein -
NL707_RS04825 (1004127) 1004127..1004621 + 495 WP_000424939.1 hypothetical protein -
NL707_RS04830 (1004792) 1004792..1005448 - 657 WP_000420456.1 protein-serine/threonine phosphatase -
NL707_RS04835 (1005798) 1005798..1006000 + 203 Protein_946 IS5/IS1182 family transposase -
NL707_RS04840 (1006073) 1006073..1006600 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL707_RS04845 (1006597) 1006597..1006887 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL707_RS04850 (1007157) 1007157..1007357 - 201 Protein_949 IS3 family transposase -
NL707_RS04855 (1007598) 1007598..1007924 + 327 WP_000393304.1 hypothetical protein -
NL707_RS04860 (1008198) 1008198..1008545 - 348 Protein_951 DUF1493 family protein -
NL707_RS04865 (1008530) 1008530..1008979 - 450 WP_000381615.1 hypothetical protein -
NL707_RS04870 (1009411) 1009411..1009854 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL707_RS04875 (1010311) 1010311..1010961 + 651 WP_023197265.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1004792..1016274 11482
- inside IScluster/Tn - - 1005824..1007357 1533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251341 WP_000971655.1 NZ_CP100747:c1006600-1006073 [Salmonella enterica subsp. enterica serovar Montevideo]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251341 WP_000855694.1 NZ_CP100747:c1006887-1006597 [Salmonella enterica subsp. enterica serovar Montevideo]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References