Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 83829..85452 Replicon plasmid pR18.0234_299k
Accession NZ_CP100745
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag FGU68_RS23275 Protein ID WP_000088046.1
Coordinates 84127..85452 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag FGU68_RS23270 Protein ID WP_024136327.1
Coordinates 83829..84122 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS23245 (FGU68_23245) 79701..80942 + 1242 WP_001053338.1 VWA domain-containing protein -
FGU68_RS23250 (FGU68_23250) 81505..81786 - 282 WP_000077926.1 hypothetical protein -
FGU68_RS23255 (FGU68_23255) 81836..82027 - 192 WP_000398480.1 hypothetical protein -
FGU68_RS23260 (FGU68_23260) 82119..82460 - 342 WP_001151575.1 hypothetical protein -
FGU68_RS23265 (FGU68_23265) 82833..83225 + 393 WP_000341066.1 hypothetical protein -
FGU68_RS23270 (FGU68_23270) 83829..84122 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
FGU68_RS23275 (FGU68_23275) 84127..85452 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
FGU68_RS23280 (FGU68_23280) 85513..85719 + 207 WP_000134171.1 hypothetical protein -
FGU68_RS23285 (FGU68_23285) 85821..86231 + 411 WP_254519581.1 hypothetical protein -
FGU68_RS23290 (FGU68_23290) 86244..87059 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
FGU68_RS23295 (FGU68_23295) 87313..87738 + 426 WP_001043843.1 hypothetical protein -
FGU68_RS23300 (FGU68_23300) 88287..88595 + 309 WP_001224687.1 hypothetical protein -
FGU68_RS23305 (FGU68_23305) 88611..89468 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / blaTEM-1B / ant(3'')-Ia / lnu(F) / sul3 / qnrS1 / dfrA12 / aadA2 / qacE / sul1 / mph(A) / aac(3)-IVa / aph(4)-Ia / floR / aph(3')-IIa - 1..299493 299493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251337 WP_000088046.1 NZ_CP100745:84127-85452 [Salmonella enterica subsp. enterica serovar Newport]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251337 WP_024136327.1 NZ_CP100745:83829-84122 [Salmonella enterica subsp. enterica serovar Newport]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References