Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4221618..4222399 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag FGU68_RS20505 Protein ID WP_000625912.1
Coordinates 4221618..4222109 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag FGU68_RS20510 Protein ID WP_001110450.1
Coordinates 4222106..4222399 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS20480 (4218500) 4218500..4219330 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
FGU68_RS20485 (4219574) 4219574..4219744 - 171 Protein_4003 adhesin biosynthesis transcription regulatory family protein -
FGU68_RS20490 (4220368) 4220368..4220511 + 144 Protein_4004 transposase -
FGU68_RS20495 (4220528) 4220528..4220874 + 347 Protein_4005 Rpn family recombination-promoting nuclease/putative transposase -
FGU68_RS20500 (4221155) 4221155..4221403 - 249 Protein_4006 IS481 family transposase -
FGU68_RS20505 (4221618) 4221618..4222109 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
FGU68_RS20510 (4222106) 4222106..4222399 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
FGU68_RS20515 (4222716) 4222716..4222938 + 223 Protein_4009 hypothetical protein -
FGU68_RS20520 (4223202) 4223202..4224077 + 876 WP_000921676.1 AraC family transcriptional regulator -
FGU68_RS20525 (4224074) 4224074..4224361 + 288 WP_001269916.1 transcriptional regulator RtsB -
FGU68_RS20530 (4224354) 4224354..4224536 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
FGU68_RS20535 (4224556) 4224556..4224655 + 100 Protein_4013 hypothetical protein -
FGU68_RS20540 (4224772) 4224772..4224906 + 135 Protein_4014 hypothetical protein -
FGU68_RS20545 (4225201) 4225201..4226106 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4214706..4224361 9655
- inside Genomic island - - 4211012..4224536 13524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T251334 WP_000625912.1 NZ_CP100744:c4222109-4221618 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT251334 WP_001110450.1 NZ_CP100744:c4222399-4222106 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References