Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4104210..4104726 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag FGU68_RS19865 Protein ID WP_000220578.1
Coordinates 4104210..4104494 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag FGU68_RS19870 Protein ID WP_000212724.1
Coordinates 4104484..4104726 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS19850 (4099422) 4099422..4101074 + 1653 WP_000155045.1 alpha,alpha-phosphotrehalase -
FGU68_RS19855 (4101483) 4101483..4103621 + 2139 WP_000187825.1 anaerobic ribonucleoside-triphosphate reductase -
FGU68_RS19860 (4103742) 4103742..4104206 + 465 WP_001268864.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FGU68_RS19865 (4104210) 4104210..4104494 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGU68_RS19870 (4104484) 4104484..4104726 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGU68_RS19875 (4104804) 4104804..4106717 - 1914 WP_001212150.1 BglG family transcription antiterminator -
FGU68_RS19880 (4106734) 4106734..4107474 - 741 WP_000779258.1 KDGP aldolase family protein -
FGU68_RS19885 (4107471) 4107471..4108589 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
FGU68_RS19890 (4108573) 4108573..4109706 - 1134 WP_000459939.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251333 WP_000220578.1 NZ_CP100744:c4104494-4104210 [Salmonella enterica subsp. enterica serovar Newport]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251333 WP_000212724.1 NZ_CP100744:c4104726-4104484 [Salmonella enterica subsp. enterica serovar Newport]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References