Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3416251..3416871 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FGU68_RS16700 Protein ID WP_001280991.1
Coordinates 3416653..3416871 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag FGU68_RS16695 Protein ID WP_000344807.1
Coordinates 3416251..3416625 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS16685 (3411390) 3411390..3412583 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FGU68_RS16690 (3412606) 3412606..3415755 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
FGU68_RS16695 (3416251) 3416251..3416625 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
FGU68_RS16700 (3416653) 3416653..3416871 + 219 WP_001280991.1 HHA domain-containing protein Toxin
FGU68_RS16705 (3417050) 3417050..3417601 + 552 WP_001278794.1 maltose O-acetyltransferase -
FGU68_RS16710 (3417718) 3417718..3418188 + 471 WP_000136181.1 YlaC family protein -
FGU68_RS16715 (3418244) 3418244..3418384 - 141 WP_001197750.1 type B 50S ribosomal protein L36 -
FGU68_RS16720 (3418390) 3418390..3418650 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
FGU68_RS16725 (3418875) 3418875..3420425 + 1551 WP_000213146.1 EAL domain-containing protein -
FGU68_RS16735 (3420656) 3420656..3421045 + 390 WP_000961287.1 MGMT family protein -
FGU68_RS16740 (3421078) 3421078..3421647 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251330 WP_001280991.1 NZ_CP100744:3416653-3416871 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251330 WP_000344807.1 NZ_CP100744:3416251-3416625 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References