Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 866421..867046 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FGU68_RS04225 Protein ID WP_000911337.1
Coordinates 866648..867046 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag FGU68_RS04220 Protein ID WP_000557545.1
Coordinates 866421..866648 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS04190 (861466) 861466..862983 + 1518 WP_000003339.1 lysine--tRNA ligase -
FGU68_RS04195 (863059) 863059..863604 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
FGU68_RS04200 (863869) 863869..864627 + 759 WP_000244328.1 amidase activator ActS -
FGU68_RS04210 (864912) 864912..865718 - 807 WP_010989071.1 DUF1460 domain-containing protein -
FGU68_RS04215 (865993) 865993..866244 - 252 WP_001540858.1 hypothetical protein -
FGU68_RS04220 (866421) 866421..866648 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
FGU68_RS04225 (866648) 866648..867046 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
FGU68_RS04230 (867853) 867853..868389 + 537 WP_001038502.1 STM3031 family outer membrane protein -
FGU68_RS04235 (868436) 868436..869068 + 633 WP_000835265.1 YfdX family protein -
FGU68_RS04240 (869787) 869787..870368 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 865993..874840 8847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T251324 WP_000911337.1 NZ_CP100744:866648-867046 [Salmonella enterica subsp. enterica serovar Newport]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT251324 WP_000557545.1 NZ_CP100744:866421-866648 [Salmonella enterica subsp. enterica serovar Newport]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References