Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1937..2496 Replicon plasmid pR18.0292_89k
Accession NZ_CP100741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag NL736_RS24395 Protein ID WP_000421257.1
Coordinates 2221..2496 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I3EQ05
Locus tag NL736_RS24390 Protein ID WP_001674495.1
Coordinates 1937..2221 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS24385 (1) 1..1032 + 1032 WP_000907867.1 plasmid replication initiator RepA -
NL736_RS24390 (1937) 1937..2221 + 285 WP_001674495.1 ribbon-helix-helix domain-containing protein Antitoxin
NL736_RS24395 (2221) 2221..2496 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL736_RS24400 (2751) 2751..3002 - 252 Protein_3 hypothetical protein -
NL736_RS24405 (2965) 2965..3939 - 975 WP_012478345.1 IS30-like element ISApl1 family transposase -
NL736_RS24410 (4118) 4118..4720 - 603 WP_094308828.1 ProQ/FINO family protein -
NL736_RS24415 (4896) 4896..5948 - 1053 WP_000655519.1 hypothetical protein -
NL736_RS24420 (6160) 6160..6750 - 591 WP_102000831.1 hypothetical protein -
NL736_RS24425 (6750) 6750..7007 - 258 WP_094308825.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(42) - 1..88662 88662
- flank IS/Tn - - 2965..3888 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T251321 WP_000421257.1 NZ_CP100741:2221-2496 [Salmonella enterica subsp. enterica serovar Typhimurium]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT251321 WP_001674495.1 NZ_CP100741:1937-2221 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3EQ05

References