Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4272693..4273474 | Replicon | chromosome |
| Accession | NZ_CP100739 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | NL736_RS20805 | Protein ID | WP_000626099.1 |
| Coordinates | 4272693..4273184 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | NL736_RS20810 | Protein ID | WP_001110452.1 |
| Coordinates | 4273181..4273474 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL736_RS20770 (4268688) | 4268688..4269263 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| NL736_RS20780 (4269534) | 4269534..4269611 | - | 78 | Protein_4059 | helix-turn-helix domain-containing protein | - |
| NL736_RS20785 (4269702) | 4269702..4270034 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| NL736_RS20790 (4270106) | 4270106..4270483 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| NL736_RS20795 (4271516) | 4271516..4271590 | + | 75 | Protein_4062 | porin family protein | - |
| NL736_RS20800 (4271693) | 4271693..4272445 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| NL736_RS20805 (4272693) | 4272693..4273184 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| NL736_RS20810 (4273181) | 4273181..4273474 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| NL736_RS20815 (4273791) | 4273791..4274012 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| NL736_RS20820 (4274277) | 4274277..4275152 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| NL736_RS20825 (4275149) | 4275149..4275436 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| NL736_RS20830 (4275459) | 4275459..4275674 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| NL736_RS20835 (4275682) | 4275682..4275951 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| NL736_RS20840 (4276245) | 4276245..4277150 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T251317 WP_000626099.1 NZ_CP100739:c4273184-4272693 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT251317 WP_001110452.1 NZ_CP100739:c4273474-4273181 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |