Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4143356..4143872 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NL736_RS20130 Protein ID WP_000220578.1
Coordinates 4143356..4143640 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL736_RS20135 Protein ID WP_000212724.1
Coordinates 4143630..4143872 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS20115 (4138568) 4138568..4140220 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NL736_RS20120 (4140629) 4140629..4142767 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL736_RS20125 (4142888) 4142888..4143352 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL736_RS20130 (4143356) 4143356..4143640 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL736_RS20135 (4143630) 4143630..4143872 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL736_RS20140 (4143950) 4143950..4145863 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NL736_RS20145 (4145880) 4145880..4146620 - 741 WP_000779263.1 KDGP aldolase family protein -
NL736_RS20150 (4146617) 4146617..4147735 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL736_RS20155 (4147719) 4147719..4148852 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251316 WP_000220578.1 NZ_CP100739:c4143640-4143356 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251316 WP_000212724.1 NZ_CP100739:c4143872-4143630 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References