Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405732..3406352 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL736_RS16615 Protein ID WP_001280991.1
Coordinates 3406134..3406352 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL736_RS16610 Protein ID WP_000344807.1
Coordinates 3405732..3406106 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS16600 (3400871) 3400871..3402064 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL736_RS16605 (3402087) 3402087..3405236 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL736_RS16610 (3405732) 3405732..3406106 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL736_RS16615 (3406134) 3406134..3406352 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL736_RS16620 (3406531) 3406531..3407082 + 552 WP_001278792.1 maltose O-acetyltransferase -
NL736_RS16625 (3407199) 3407199..3407669 + 471 WP_000136181.1 YlaC family protein -
NL736_RS16630 (3407725) 3407725..3407865 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL736_RS16635 (3407871) 3407871..3408131 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL736_RS16640 (3408356) 3408356..3409906 + 1551 WP_000213139.1 EAL domain-containing protein -
NL736_RS16650 (3410137) 3410137..3410526 + 390 WP_000961285.1 MGMT family protein -
NL736_RS16655 (3410559) 3410559..3411128 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251312 WP_001280991.1 NZ_CP100739:3406134-3406352 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251312 WP_000344807.1 NZ_CP100739:3405732-3406106 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References