Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838302..838962 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL736_RS04035 Protein ID WP_000244756.1
Coordinates 838549..838962 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL736_RS04030 Protein ID WP_000351186.1
Coordinates 838302..838568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS04010 (834230) 834230..835663 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NL736_RS04015 (835822) 835822..836133 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL736_RS04020 (836297) 836297..836956 + 660 WP_000250289.1 hemolysin III family protein -
NL736_RS04025 (837072) 837072..838052 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
NL736_RS04030 (838302) 838302..838568 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL736_RS04035 (838549) 838549..838962 + 414 WP_000244756.1 protein YgfX Toxin
NL736_RS04040 (839015) 839015..839536 - 522 WP_001055885.1 flavodoxin FldB -
NL736_RS04045 (839649) 839649..840545 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL736_RS04050 (840569) 840569..841282 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL736_RS04055 (841288) 841288..843021 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251304 WP_000244756.1 NZ_CP100739:838549-838962 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251304 WP_000351186.1 NZ_CP100739:838302-838568 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References