Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206531..207291 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NL736_RS00970 Protein ID WP_000533909.1
Coordinates 206806..207291 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NL736_RS00965 Protein ID WP_000965886.1
Coordinates 206531..206818 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS00940 (201826) 201826..202128 + 303 WP_000605590.1 YsaB family lipoprotein -
NL736_RS00945 (202267) 202267..203178 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NL736_RS00950 (203188) 203188..205257 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
NL736_RS00955 (205439) 205439..205714 + 276 Protein_189 IS3 family transposase -
NL736_RS00960 (205886) 205886..206353 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NL736_RS00965 (206531) 206531..206818 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NL736_RS00970 (206806) 206806..207291 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NL736_RS00975 (207663) 207663..208202 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
NL736_RS00980 (208376) 208376..208588 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NL736_RS00985 (208877) 208877..209167 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NL736_RS00990 (209606) 209606..210316 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NL736_RS00995 (210366) 210366..211340 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
NL736_RS01000 (211559) 211559..212221 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251301 WP_000533909.1 NZ_CP100739:206806-207291 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251301 WP_000965886.1 NZ_CP100739:206531-206818 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References