Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 17646..18319 Replicon plasmid pACMV3
Accession NC_015179
Organism Acidiphilium multivorum AIU301

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ACMV_RS18780 Protein ID WP_148360932.1
Coordinates 17646..18044 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ACMV_RS18785 Protein ID WP_013635100.1
Coordinates 18059..18319 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACMV_RS18755 13598..14641 - 1044 WP_013635094.1 ABC transporter permease -
ACMV_RS18760 14662..16317 - 1656 WP_041665874.1 ABC transporter substrate-binding protein -
ACMV_RS18765 16586..16858 - 273 WP_013635096.1 type II toxin-antitoxin system RelE/ParE family toxin -
ACMV_RS18770 16842..17066 - 225 WP_013635097.1 TraY domain-containing protein -
ACMV_RS18775 17335..17649 - 315 Protein_20 IS1634 family transposase -
ACMV_RS18780 17646..18044 - 399 WP_148360932.1 type II toxin-antitoxin system VapC family toxin Toxin
ACMV_RS18785 18059..18319 - 261 WP_013635100.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ACMV_RS18790 18410..19327 - 918 WP_013635101.1 hypothetical protein -
ACMV_RS18795 19426..20133 - 708 WP_013635102.1 mobilization protein -
ACMV_RS18800 20130..20618 - 489 WP_013635103.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..54248 54248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

SpoVT-AbrB domain

(10-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14245.64 Da        Isoelectric Point: 7.3600

>T25130 WP_148360932.1 NC_015179:c18044-17646 [Acidiphilium multivorum AIU301]
MLDTNTVSHLIRQHPAVTRRVVEMPMATLCISVITEGELLFGLARRPKATALHQVVKELLRRIDVLAWDSSTAGIYGTLR
AGLTATGRTMGPLDLLIAAHAIATGSVLVTNDQAFRMIDGLAVDDWTMPSPA

Download         Length: 399 bp

>T25130 NC_015179:c18044-17646 [Acidiphilium multivorum AIU301]
ATGCTGGACACTAACACGGTAAGTCATCTGATCAGGCAGCATCCCGCGGTCACCCGGCGCGTGGTCGAAATGCCCATGGC
CACCTTGTGCATCTCCGTGATCACCGAAGGCGAGTTGCTGTTTGGCCTGGCTAGACGGCCGAAGGCAACCGCACTGCATC
AGGTAGTCAAGGAATTGCTGCGACGGATCGATGTCCTGGCCTGGGATAGCTCCACGGCAGGAATTTACGGCACCCTCCGC
GCCGGTCTGACGGCTACCGGCAGGACCATGGGGCCGCTCGATCTGCTGATCGCTGCCCACGCCATCGCCACAGGATCCGT
CCTGGTGACCAACGATCAGGCGTTCCGCATGATCGACGGGCTGGCGGTCGACGATTGGACGATGCCGTCTCCCGCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9854.02 Da        Isoelectric Point: 6.3276

>AT25130 WP_013635100.1 NC_015179:c18319-18059 [Acidiphilium multivorum AIU301]
MSQIAKLFNNGRSQAVRLPAAYRFEGAEVFIRRDPDSGDVILSRRPADWEGFFAILRNTKVPADFLDRSERNQGVQERDP
FAGWPE

Download         Length: 261 bp

>AT25130 NC_015179:c18319-18059 [Acidiphilium multivorum AIU301]
ATGAGCCAGATCGCCAAACTCTTTAATAACGGCAGAAGCCAGGCCGTCCGCCTGCCCGCGGCCTATCGCTTCGAGGGCGC
CGAGGTCTTCATCCGCCGCGATCCCGATAGCGGTGACGTCATCCTGTCCCGACGACCAGCGGATTGGGAAGGGTTTTTCG
CTATTCTCCGTAACACAAAAGTGCCGGCTGATTTTCTTGATCGGTCAGAGCGGAACCAGGGCGTTCAAGAGCGCGATCCC
TTCGCCGGCTGGCCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References