Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84084..85707 Replicon plasmid pR18.1477_259k
Accession NZ_CP100737
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NL742_RS23580 Protein ID WP_000088046.1
Coordinates 84382..85707 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NL742_RS23575 Protein ID WP_024136327.1
Coordinates 84084..84377 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS23550 (NL742_23550) 79956..81197 + 1242 WP_001053338.1 VWA domain-containing protein -
NL742_RS23555 (NL742_23555) 81760..82041 - 282 WP_000077926.1 hypothetical protein -
NL742_RS23560 (NL742_23560) 82091..82282 - 192 WP_000398480.1 hypothetical protein -
NL742_RS23565 (NL742_23565) 82374..82715 - 342 WP_001151575.1 hypothetical protein -
NL742_RS23570 (NL742_23570) 83088..83480 + 393 WP_000341066.1 hypothetical protein -
NL742_RS23575 (NL742_23575) 84084..84377 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NL742_RS23580 (NL742_23580) 84382..85707 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NL742_RS23585 (NL742_23585) 85768..85974 + 207 WP_000134171.1 hypothetical protein -
NL742_RS23590 (NL742_23590) 86076..86486 + 411 WP_000985911.1 hypothetical protein -
NL742_RS23595 (NL742_23595) 86499..87314 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
NL742_RS23600 (NL742_23600) 87568..87993 + 426 WP_001043843.1 hypothetical protein -
NL742_RS23605 (NL742_23605) 88542..88850 + 309 WP_001224687.1 hypothetical protein -
NL742_RS23610 (NL742_23610) 88866..89723 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / aph(3')-IIa / tet(A) / dfrA12 / aadA2 / qacE / sul1 / mph(A) / aac(3)-IVa / aph(4)-Ia / floR - 1..258626 258626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251299 WP_000088046.1 NZ_CP100737:84382-85707 [Salmonella enterica subsp. enterica serovar Agona]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251299 WP_024136327.1 NZ_CP100737:84084-84377 [Salmonella enterica subsp. enterica serovar Agona]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References