Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4111636..4112279 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag NL742_RS19815 Protein ID WP_000048134.1
Coordinates 4111863..4112279 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NL742_RS19810 Protein ID WP_001261294.1
Coordinates 4111636..4111866 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS19800 (4108650) 4108650..4110788 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
NL742_RS19805 (4111005) 4111005..4111469 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL742_RS19810 (4111636) 4111636..4111866 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NL742_RS19815 (4111863) 4111863..4112279 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
NL742_RS19820 (4112340) 4112340..4114253 - 1914 WP_001212127.1 BglG family transcription antiterminator -
NL742_RS19825 (4114270) 4114270..4115010 - 741 WP_000779249.1 KDGP aldolase family protein -
NL742_RS19830 (4115007) 4115007..4116125 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL742_RS19835 (4116109) 4116109..4117242 - 1134 WP_000459942.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T251296 WP_000048134.1 NZ_CP100736:4111863-4112279 [Salmonella enterica subsp. enterica serovar Agona]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT251296 WP_001261294.1 NZ_CP100736:4111636-4111866 [Salmonella enterica subsp. enterica serovar Agona]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References