Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4042089..4043727 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name hipA Uniprot ID B5F4A8
Locus tag NL742_RS19460 Protein ID WP_001255026.1
Coordinates 4042089..4043417 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag NL742_RS19465 Protein ID WP_001099274.1
Coordinates 4043422..4043727 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS19440 (4037627) 4037627..4038610 + 984 WP_000210270.1 toll/interleukin-1 receptor domain-containing protein -
NL742_RS19445 (4038879) 4038879..4039406 - 528 WP_001043245.1 hypothetical protein -
NL742_RS19450 (4039403) 4039403..4040599 - 1197 WP_000542997.1 hypothetical protein -
NL742_RS19455 (4040788) 4040788..4041777 - 990 WP_077905772.1 restriction endonuclease -
NL742_RS19460 (4042089) 4042089..4043417 - 1329 WP_001255026.1 type II toxin-antitoxin system HipA family toxin Toxin
NL742_RS19465 (4043422) 4043422..4043727 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
NL742_RS19470 (4044474) 4044474..4044944 + 471 WP_001222753.1 hypothetical protein -
NL742_RS19480 (4046482) 4046482..4046718 + 237 WP_001748005.1 conjugal transfer protein TraG N-terminal domain-containing protein -
NL742_RS19485 (4046835) 4046835..4048223 - 1389 WP_254522760.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fosA7 - 4028203..4072068 43865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50786.57 Da        Isoelectric Point: 5.0474

>T251294 WP_001255026.1 NZ_CP100736:c4043417-4042089 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT251294 WP_001099274.1 NZ_CP100736:c4043727-4043422 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4S6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References