Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3428408..3429028 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL742_RS16615 Protein ID WP_001280991.1
Coordinates 3428810..3429028 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL742_RS16610 Protein ID WP_000344807.1
Coordinates 3428408..3428782 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS16600 (3423547) 3423547..3424740 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL742_RS16605 (3424763) 3424763..3427912 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL742_RS16610 (3428408) 3428408..3428782 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL742_RS16615 (3428810) 3428810..3429028 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL742_RS16620 (3429207) 3429207..3429758 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL742_RS16625 (3429876) 3429876..3430346 + 471 WP_000136183.1 YlaC family protein -
NL742_RS16630 (3430402) 3430402..3430542 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL742_RS16635 (3430548) 3430548..3430808 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL742_RS16640 (3431033) 3431033..3432583 + 1551 WP_000213148.1 EAL domain-containing protein -
NL742_RS16650 (3432814) 3432814..3433203 + 390 WP_000961286.1 MGMT family protein -
NL742_RS16655 (3433236) 3433236..3433805 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251291 WP_001280991.1 NZ_CP100736:3428810-3429028 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251291 WP_000344807.1 NZ_CP100736:3428408-3428782 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References