Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 853304..853964 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL742_RS04150 Protein ID WP_000244756.1
Coordinates 853551..853964 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL742_RS04145 Protein ID WP_000351186.1
Coordinates 853304..853570 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS04125 (849232) 849232..850665 - 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -
NL742_RS04130 (850824) 850824..851138 + 315 WP_001182977.1 N(4)-acetylcytidine aminohydrolase -
NL742_RS04135 (851299) 851299..851958 + 660 WP_000250289.1 hemolysin III family protein -
NL742_RS04140 (852074) 852074..853054 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NL742_RS04145 (853304) 853304..853570 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL742_RS04150 (853551) 853551..853964 + 414 WP_000244756.1 protein YgfX Toxin
NL742_RS04155 (854017) 854017..854538 - 522 WP_001055885.1 flavodoxin FldB -
NL742_RS04160 (854651) 854651..855547 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL742_RS04165 (855571) 855571..856284 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL742_RS04170 (856290) 856290..858023 + 1734 WP_000813397.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251283 WP_000244756.1 NZ_CP100736:853551-853964 [Salmonella enterica subsp. enterica serovar Agona]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251283 WP_000351186.1 NZ_CP100736:853304-853570 [Salmonella enterica subsp. enterica serovar Agona]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References